The PORTEC-3 trial investigated the benefit of combined adjuvant chemotherapy and radiotherapy (CTRT) versus radiotherapy alone (RT) for women with stage I-III endometrial cancer with high-risk features (HREC). Since the TCGA defined 4 molecular subgroups of EC with strong prognostic value, we investigated outcomes and impact of chemotherapy …
Lancet Oncol 2018; 19(3):295e309. [2] de Boer SM, Powell ME, Mileshkin L, Katsaros D, Bessette P, Haie-Meder C, et al. Adjuvant chemoradiotherapy versus radiotherapy alone in women with high-risk endometrial cancer (PORTEC-3): patterns of recurrence and post-hoc. survival analysis of a randomised phase 3 trial. Lancet Oncol 2019;20(9):1273 1285.
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Molecular classification has strong prognostic value in high-risk EC, with significantly improved RFS with adjuvant CTRT for p53abn tumors, regardless of histologic type. PURPOSE The randomized Adjuvant Chemoradiotherapy Versus Radiotherapy Alone in Women With High-Risk Endometrial Cancer (PORTEC-3) trial investigated the benefit of …
3 1 Samples' DNA were sequenced using the AmpliSeq Cancer Hotspot Panel V.5, a panel consisting of 2 two primer pools designed to detect somatic cancer hotspot mutations covering 82 genes, including 3 the complete POLE exonuclease domain and TP53.Libraries were prepared using 42-84ng of DNA 4 and each sample labelled with a unique barcode …
The average score for the survey factors was 4.06 for the first part of the food service category, and 3.64 for food quality, 4.11 for health services, 3.92 for hygiene and sanitation. An average rating of passengers' satisfaction or satisfaction was 3.78 and the desire to relinquish was 3.97 points. The SERVQUAL model is the food safety factor ...
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Methods In the multicentre randomised phase 3 PORTEC-3 trial, women with high-risk endometrial cancer were eligible if they had International Federation of Gynaecology and Obstetrics (FIGO) 2009 stage I, endomeid grade 3 cancer with deep myometrial invasion or lymphovascular space invasion, or both; stage II or III disease; or stage I–III